Signs and symptoms[ edit ] A diagram showing the cells affected by CLL Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. This is referred to as small lymphocytic lymphoma.
Prognosis and survival depend on many factors. A prognostic factor is an aspect of the cancer or a characteristic of the person that the doctor will consider when making a prognosis. A predictive factor influences how a cancer will respond to a certain treatment. Prognostic and predictive factors are often discussed together and they both play a part in deciding on a treatment plan and a prognosis.
The following are prognostic and predictive factors for CLL. Stage A lower stage at the time of diagnosis is a more favourable prognostic factor.
Leukemia cells in the bone marrow Abnormal blood cells called leukemia cells can form different patterns in the bone marrow. When the leukemia cells are more spread out called a diffuse pattern it is a less favourable prognostic factor. Leukemia cells that are in small clumps called a nodular pattern or leukemia cells between normal cells called an interstitial pattern are more favourable prognostic factors.
Age Elderly people have a less favourable prognosis. Sex Men have a less favourable prognosis than women. Chromosome changes Deletion of part of chromosome 13, with no other chromosome abnormalities, is a more favourable prognostic factor.
Deletion of parts of chromosome 11 or 17 is a less favourable prognostic factor. Prolymphocytic transformation A prolymophocyte is an early form of a lymphocyte.
A higher number of prolymphocytes in the blood is called prolymphocytic transformation. It has a less favourable prognosis. Lymphocyte doubling time Lymphocyte doubling time is the time it takes for the lymphocyte count to double.
A lymphocyte doubling time of more than 6 months is a more favourable prognostic factor. Areas of lymphatic tissue affected The areas of lymphatic tissue are the spleen, liver and lymph nodes in the neck, underarm area and groin.
Having fewer areas of lymphatic tissue areas affected by CLL is a more favourable prognostic factor. Protein levels The following protein levels mean a more favourable prognosis: Performance status People with a good performance status at the time of diagnosis have a more favourable prognosis.Risk factors for developing CLL/SLL.
The causes (etiology) of CLL and lymphomas are not yet known. There could be many contributing factors that lead to it development over time, such as advancing age, inherited disposition, exposures to chemicals or radiation, and chance.
Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The landscape of treatment for relapsed chronic lymphocytic leukemia (CLL) has recently changed with the introduction of agents that inhibit intracellular B-cell receptor signaling.
1,2 Ibrutinib. Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL).
RS occurs in approximately 2% to 10% of CLL patients during the course of their disease, with a transformation rate of %.
Why should chronic lymphocytic leukemia (CLL) patients be concerned about Richter’s transformation? Noted CLL expert Dr. Stephen Spurgeon from OHSU Knight Cancer Institute explains what it means for CLL treatment, how .
Editorial. Once before, we wrote about a transplant program at the National Institutes of Health (see Stem Cell Transplants - Almost Free of Charge).A lot of our members read the article and were deeply interested in this option.